Neurobiology of Disease A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A Pathology and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease
نویسندگان
چکیده
Hiroaki Fukumoto,1* Hideki Takahashi,1* Naoki Tarui,1 Junji Matsui,1 Taisuke Tomita,2 Mitsuhiro Hirode,1 Masumi Sagayama,1 Ryouta Maeda,1 Makiko Kawamoto,1 Kazuko Hirai,1 Jun Terauchi,1 Yasufumi Sakura,1 Mitsuru Kakihana,1 Kaneyoshi Kato,1 Takeshi Iwatsubo,2,3 and Masaomi Miyamoto1 1Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa-ku, Osaka 532-8686, Japan, and 2Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, and 3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
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